Alentis Therapeutics, a Basel, Switzerland-based clinical-stage biotech company, raised $181.4M in Series D funding.
The round was led by OrbiMed, with Novo Holdings and Jeito Capital with participation from Frazier Life Sciences, Longitude Capital, Catalio Capital, Piper Heartland Healthcare Capital, Avego Bioscience Capital, RA Capital Management, Morningside Venture Investments, BB Pureos and BPI France through its InnoBio 2 fund.
The company intends to use the funds to begin Phase 1/2 trials for two first-in-class ADCs: ALE.P02, which targets advanced or metastatic CLDN1+ squamous solid tumours with a tubulin inhibitor payload, and ALE.P03, which targets CLDN1+ tumours with a distinct topoisomerase I inhibitor payload.
Led by CEO Roberto Iacone, Alentis Therapeutics is a clinical-stage biotech developing breakthrough treatments for CLDN1+ tumours. CLDN1 is a previously unexploited target that plays a key role in the pathology of cancer and fibrotic disease. Alentis is the leading company pioneering anti-CLDN1 ADCs and antibodies to modify and reverse the course of select diseases.
FDA clearance is already obtained for ALE.P02, with clinical trials expected to commence in Q1 2025. For ALE.P03, a first-in-human trial in patients with CLDN1+ tumours is subsequently planned to start in 2025.
FinSMEs
12/11/2024